Saoirse-Monica Jackson

Jackson's television debut came in 2016 when she landed the role of Sasha in Harlan Coben's The Five, appearing in four episodes. In 2016, she also played Curley's wife in the Birmingham Repertory Theatre tour of John Steinbeck's Of Mice and Men. She appeared briefly in the final episode of 2017 BBC One drama series Broken. In 2018, she portrayed Shena Carney in a West End production of The Ferryman at the Gielgud Theatre.

Jackson made her debut as Erin Quinn in the Channel 4 sitcom Derry Girls in the show's first episode, airing on Channel 4 on 4 January 2018. Her performance saw her nominated for the IFTA Gala Television Award for Best Female Performance. She portrayed the role for three seasons until the conclusion of the series in May 2022.

She appeared in an episode of The Great British Bake Off: Festive Specials.

On 26 June 2020, she and her fellow Derry Girls co stars performed a sketch with Saoirse Ronan for the RTÉ fundraising special RTÉ Does Comic Relief. All proceeds from the night went towards those affected by the COVID-19 pandemic.

In 2025, she played the role of Cheryl Crawford, wife of Davey Crawford (portrayed by Stephen Walters), in the BBC One Liverpool-based gangster television series, This City Is Ours (2025)